Omeprazole (a proton pump inhibitor) is used in treatment of ulcers and reflux oseophagitis and Domperidone (prokinetic and antiemetic properties) is used for relief on nausea and vomiting of any cause, uremia and reflux oesophagitis.
Domperidone is a dopamine antagonist with antiemetic properties, used in the treatment of nausea and vomiting. Domperidone acts by increasing lower esophageal sphincter tone and by enhancing upper gastrointestinal tract (GIT) motility and thus acts on one of the pathophysiological mechanisms of GERD.
A combination therapy of a prokinetic agent and a gastric acid lowering compound is rational and has shown more effectiveness than mono-therapy of proton pump inhibitors
However, prokinetic agents such as domperidone require optimum binding to receptors. Hence, improved therapeutic efficacy may be achieved by administering the drug in timed release form with an initial loading dose and a delayed release dose provided with a lag time.
Immediate release, as the name implies, dissolves immediately within our stomachs and is taken up into the bloodstream as it is also taken up quickly and then degraded quickly. So the concentration of the drug does not stay constant in our bodies, and the drug is quickly degraded.
Omeprazole and Domperidone SR (20mg + 30mg)
Omeprazole and Domperidone IR (20mg + 10mg)
Omeprazole and Domperidone IR (`10mg + 10mg)
Omeprazole and Domperidone Pellets Manufacturer & Supplier
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